研究業績
主な英文論文
- 1.
- Shiraishi I. Basic and Comprehensive Outlines of Cardiovascular Embryology and Morphogenesis. Journal of Pediatric Cardiology and Cardiac Surgery 4: 63-74.
- 2.
- Hoashi T, Ichikawa H, Nakata T, Shimada M, Ozawa H, Higashida A, Kurosaki K, Kanzaki S, Shiraishi I. Utility of a super-flexible three- dimensional printed heart model in congenital heart surgery. Interact Cardiovasc Thorac Surg. 2018 May 28. doi: 10.1093/icvts/ivy160
- 3.
- Shiraishi I, Nishimura K, Sakaguchi H, Abe T, Kitano M, Kurosaki K, Kato H, Nakanishi T, Yamagishi H, Sagawa K, Ikeda Y, Morisaki T, Hoashi T, Kagisaki K, Ichikawa H. Acute rupture of chordae tendineae of the mitral valve in infants: a nationwide survey in Japan exploring a new syndrome. Circulation. 2014;130:1053-61.
- 4.
- Shiraishi I, Kajiyama Y, Yamagishi M, Hamaoka K, Yagihara T. The applications of non-ECG-gated MSCT angiography in children with congenital heart disease. Int J Cardiol. 2012;156:309-14.
- 5.
- Shiraishi I, Ichikawa H. Human heterotaxy syndrome – from molecular genetics to clinical features, management, and prognosis. Circ J. 2012;76(9):2066-75.
- 6.
- Shiraishi I, Yamagishi M, Hamaoka K, Fukuzawa M, Yagihara T. Simulative operation on congenital heart disease using rubber-like urethane stereolithographic biomodels based on 3D datasets of multislice computed tomography. Eur J Cardiothorac Surg. 2010;37:302-6.
- 7.
- Yamamoto Y, Shiraishi I, Dai P, Hamaoka K, Takamatsu T. Regulation of embryonic lung vascular development by vascular endothelial growth factor receptors, Flk-1 and Flt-1. Anat Rec. 2007;290:958-73.
- 8.
- Sato H, Shiraishi I, Takamatsu T, Hamaoka K. Detection of TUNEL-positive cardiomyocytes and c-kit-positive progenitor cells in children with congenital heart disease. J Mol Cell Cardiol. 2007;43:254-61.
- 9.
- Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA. Nuclear targeting of Akt antagonizes cardiomyocyte hypertrophy. Proc Natl Acad Sci USA. 2006;103:11946-51.
- 10.
- Shiraishi I, Kajiyama Y, Yamagishi M, Hamaoka K. Stereolithographic biomodeling of congenital heart disease by multislice computed tomography imaging. Circulation. 2006;113:e733-4.
- 11.
- Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res. 2004;94:884-91.
- 12.
- Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A. Cardiac stem cell and myocyte aging, heart failure, and IGF-1 overexpression. Circ Res. 2004;94:514-24.
- 13.
- Shiraishi I, Yamamoto Y, Ozawa S, Kawakita A, Toiyama K, Tanaka T, et al. Application of helical computed tomographic angiography with differential color imaging 3D reconstruction in the diagnosis of complicated congenital heart diseases. J Thorac Cardiovasc Surg. 2003;125:36-9.
- 14.
- Shiraishi I, Kato Y, Todoroki H, Satoh H, Hamaoka K. Images in cardiovascular medicine. Differential color imaging technique of helical CT angiography in the diagnosis of total anomalous pulmonary venous drainage. Circulation. 2000;101:2017-8.
- 15.
- Shiraishi I, Simpson DG, Carver W, Borg TK et al. Vinculin is an essential component for normal myofibrillar arrangement in fetal mouse cardiac myocytes. J Mol Cell Cardiol. 1997;29:2041-52.
- 16.
- Shiraishi I, Takamatsu T, Price RL, Fujita S. Temporal and spatial patterns of phosphotyrosine during cardiac myofibrillogenesis of chicken embryo. Anat Embryol 1997;196:81-9.
- 17.
- Shiraishi I, Takamatsu T, Fujita S. Three-dimensional observation with a confocal scanning laser microscope of fibronectin immunolabeling during cardiac looping in the chick embryo. Anat Embryol. 1995;191:183-9.
- 18.
- Shiraishi I, Takamatsu T, Minamikawa T, Onouchi Z, Fujita S. Quantitative histological analysis of the human sinoatrial node during growth and aging. Circulation. 1992;85:2176-84.
- 19.
- Shiraishi I, Takamatsu T, Fujita S. 3-D observation of N-cadherin expression during cardiac myofibrillogenesis of the chick embryo using a confocal laser scanning microscope. Anat Embryol. 1993;187:115-20.
- 20.
- Shiraishi I, Takamatsu T, Minamikawa T, Fujita S. 3-D observation of actin filaments during cardiac myofibrinogenesis in chick embryo using a CLSM. Anat Embryol. 1992;185:401-8.
英文Book chapters
- 1
- Shiraishi I. Left-Right Asymmetry and Human Heterotaxy Syndrome. In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. Tokyo: Springer; 2016. Chapter 6.
- 2
- Shiraishi I, Left-Right Asymmetry and Human Heterotaxy Syndrome. Etiology and Morphogenesis of Congenital Heart Disease. From Gene Function and Cellular Interaction to Morphology. Eds: Nakanishi T, Markwald RR, Baldwin HS. Springer, 2016, pp49-56.
- 3
- Shiraishi I, Takamatsu T, Hamaoka K. Signal transduction during cardiac myofibrillogenesis and looping. In Cardiovascular Development and Congenital Heart Disease. Molecular and Genetic Mechanisms. Eds: Artman M, Benson w, Srivastava D, Nakazawa M. Blackwell Futura, 2005, pp17-19.
- 4
- Shiraishi I, Takamatsu T, Onouchi Z, Borg TK. Cell-cell and cell-matrix adhesions during formation and arrangement of developing cardiac myofibrils. In etiology and Morphogenesis of Congenital Heart Disease: Twenty years of progress in genetics and developmenta;l biology. Eds: Clark EB, Nakazawa M, Taao A. Futura Publishing Co, Inc., 2000, pp175-180.
- 5
- Shiraishi I, Takamatsu T, Onouchi Z, Fujita S. Three-dimensional observation of F-actin and expression of N-cadherin and fibronectin during cardiac looping of the chick embryo using CLSM. In Developmental Mechanisms of Heart Disease. Eds: Clark EB, Markward RR, Takao A. Futura Publising Co, Inc., 1995, pp465-476.
日本語編集著書
- 1
- 新先天性心疾患を理解するための臨床心臓発生学, 第2版. 編集:山岸敬幸、白石公. メジカルビュー社、東京、2021.
- 2
- Fontan循環. 編集:市川肇、大内肇、黒嵜健一、白石公. 診断と治療社、東京、2020.
- 3
- 小児•成育循環器学. 編集:日本小児循環器学会(編集委員長白石公). 診断と治療社、東京、2018.
- 4
- 先天性心疾患を理解するための臨床心臓発生学. 編集:山岸敬幸、白石公. メジカルビュー社、東京、2007.
- 5
- 先天性心疾患におけるヘリカルCT診断. 編集:濱岡建城、白石公. メディカルセンス社、東京2004.
競争的研究資金(過去5年間、白石の主な研究に限る)
- 1
- 日本学術振興会・科学研究費補助金事業・基盤研究C. 2022-2024年度. 乳児特発性僧帽弁腱索断裂の病因解明のためのFFPE標本を用いたウイルスRNA解析(代表者:黒嵜健一)
- 2
- 厚生労働省 難治性疾患等政策研究事業 2021−2023年度「先天性心疾患を主体とする小児期発症の心血管難治性疾患の救命率の向上と生涯にわたるQOL改善のための総合的研究」(代表者:白石公)
- 3
- 日本医療研究開発機構 先進的医療機器・システム等技術開発事業. 2020-2022年度.「小児先天性心疾患患者の生涯にわたるQOL改善を目指した、最適な治療方針決定のためのマルチスケール・マルチフィジックス心臓シミュレータ“ped UT-Heart”の開発と事業化(代表者:白石公)
- 4
- 日本学術振興会・科学研究費補助金事業・基盤研究C. 2019-2021年度.乳児特発性僧帽弁腱索断裂の病因解明のためのトランスクリプトーム・メタゲノム解析(代表者:白石公)
- 5
- 厚生労働省 難治性疾患等政策研究事業 2018−2020年度「先天性心疾患を主体とする小児期発症の心血管難治性疾患の生涯にわたるQOL改善のための診療体制の構築と医療水準の向上に向けた総合的研究」(代表者:白石公)
- 6
- 日本医療研究開発機構・医工連携事業化推進事業 2017−2019年度、「立体構造が極めて複雑な先天性心疾患患者への3Dモデル診断による術時間削減を実現する、オーダーメイド型超軟質3D精密心臓モデルの開発・事業化」、(リーダー:竹田正俊、サブリーダー:白石)
- 7
- 日本医療研究開発機構・医療機器開発推進研究事業 2014−2016年度、「超軟質精密心臓レプリカの作成による心臓外科手術トレーニングと個別化医療の確立に向けた研究」(代表者:白石公)
- 8
- 厚生労働省 難治性疾患等政策研究事業 2015−2017年度「先天性心疾患児の成人期以降も含めた長期予後の把握のあり方に関する研究」(代表者:白石公)
- 9
- 厚生労働省 厚生労働科研 2016-2017年度. 乳児特発性僧帽弁腱索断裂の多彩な病因に基づいた治療法の確立に向けた研究(代表者:白石公)
国際特許
- 1
- PTC-international patent:PTC/JP2010/061249, ”Method for producing resin modeled body and hollow structure body, and core”
- 2
- PTC- international patent: PCT/JP2018/00371 ”VERIFICATION METHOD AND VERIFICATION SYSTEM FOR INTERAL ORGAN MODEL”